How SPICULE
Transforms Skin
From micro-channel formation to cellular regeneration — we explain SPICULE's two core mechanisms of action.
Spicule's Dual-Phase Action Mechanism
BSPN spicules are not simple delivery vehicles — they perform a Dual-Phase action: physical microporation → cell regeneration → natural release, making them a multifunctional cosmetic ingredient.
↑ Click each card to view detailed mechanism for each phase
Transdermal Drug Delivery Through Micro-Channels
When applied to skin, SPICULE creates micro-channels in the stratum corneum through physical friction. Through these channels, transdermal absorption of active ingredients is dramatically enhanced. Up to 19.4× improvement in Hyaluronic Acid (HA) absorption (based on SFLS system).
SPICULE penetrates the stratum corneum, forming micro-channels of average 48.6μm depth
Channels remain open and gradually close over up to 120 hours (5 days)
Active ingredients (ampoules, serums, etc.) are absorbed transdermally through the channels
Ingredients are delivered to the basal layer, accelerating the skin regeneration cycle
Transdermal Absorption Rate by Method
Microchannel Formation
16,000/cm²
Skin Implant Effect
Sustained
Dermal Targeted Delivery
4.9×
Penetration Enhancement by Ingredient
Total Active Ingredients
4.9×
vs. standard applicationInsulin (macromolecule)
91×
vs. standard applicationNiacinamide
2.9×
vs. standard applicationsiRNA (nucleic acid)
73×
vs. standard applicationBSPN Spicule's Differentiation vs. Other Ingredients
BSPN spicule is the only ingredient category combining physical delivery + cell regeneration + natural release in one material.
| Function | BSPN Spicule | Polymer Microneedle | Generic Synthetic Silica | Collagen Booster Peptide |
|---|---|---|---|---|
| Physical Microchannel Formation | ✓ 16,000/cm² | ✓ (limited depth) | ✗ | ✗ |
| Macromolecule Dermal Delivery | ✓ Penetration 4.9× | △ With patch only | ✗ | ✗ Self only |
| Cell Regeneration (Growth Factors) | ✓ TGF-β·EGF·FGF | △ Weak | ✗ | ✗ |
| Direct Collagen Synthesis | ✓ 1.8× increase | ✗ | ✗ | △ Concentration/stability limits |
BSPN Spicule = "Triple-Action" Integrated Ingredient
Combines delivery vehicle + regeneration agent + collagen booster in one ingredient. While other categories provide only 1–2 functions, BSPN is the only multi-functional ingredient meeting all 5 functions.
Academic & Technical References
All data, charts, and mechanism explanations on this page are based on peer-reviewed primary literature.
- 1Kim TG, Lee Y, Kim MS, Lim J. (2022). A novel dermal delivery system using natural spicules for cosmetics and therapeutics. J Cosmet Dermatol, 21(10), 4754–4764. DOI: 10.1111/jocd.14771.
- 2Reffitt DM, Ogston N, Jugdaohsingh R, et al. (2003). Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone, 32(2), 127–135. PMID: 12633784.
- 3Drozdov AL, Zemnukhova LA, Panasenko AE, et al. (2021). Silicon Compounds in Sponges. Applied Sciences, 11(14), 6587. DOI: 10.3390/app11146587.
- 4Udompataikul M, Wongniraspai T. (2012). The study on effects and safety of Spongilla lacustris in 3% hydrogen peroxide solution on rat skin. J Med Assoc Thai, 95(Suppl 12), S15–S20. PMID: 23513460.
- 5Jurkić LM, Cepanec I, Pavelić SK, Pavelić K. (2013). Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds. Nutr Metab (Lond), 10(1), 2. PMC3546016.
- 6Quignard S, Coradin T, Powell JJ, Jugdaohsingh R. (2017). Silica nanoparticles as sources of silicic acid favoring wound healing in vitro. Colloids Surf B Biointerfaces.
- 7Waghule T, et al. (2019). Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomedicine & Pharmacotherapy, 109, 1249–1258.
- 8Prausnitz MR, Langer R. (2008). Transdermal drug delivery. Nature Biotechnology, 26(11), 1261–1268.
- 9Zhang C, Zhang K, Zhang J, et al. (2019). Skin delivery of hyaluronic acid by the combined use of sponge spicules and flexible liposomes. Biomaterials Science, 7(7), 2821–2831. PMID: 30821312.
- 11UNIZ LAB R&D data — 99.8% high-purity, ~10.59 million particles per gram (270µm), 23-step eco-enzyme purification process.
- 12Dong-A University EDS / XRD analysis report — Si 36.3% / O 51.8% / C 11.9%, X-ray amorphous pattern verified.
- 13Protechkorea Test Report (2022) — BET surface area 0.5968 m²/g (TriStar II 3020) / Density 2.0417 g/cm³ (AccuPyc II 1340, 5-cycle average ±0.0016).