OEM / ODM
Custom manufacturing partnership
From ingredient to finished product — a spicule finished-product partnership that looks after formulation development, stability, and certification with you.
Partnership inquirySiO₂·nH₂O · a natural mineral microneedle from freshwater spongeWe study spicules.
We study spicules.
How they work the moment they touch skin, examined at the very source.
Physically opening fine channels in the stratum corneum, a natural mineral microneedle — it carries active ingredients close to the skin's depths and gently supports the skin's own rhythm of letting dulled surface cells fall away: penetration and turnover, a two-step principle. UNIZ LAB is the world's largest manufacturer of spicule ingredients.
99.8%Purity
73.4%Dermal absorption (pectolinarin, porcine) (Kim 2022)
50+Export
15yrResearch
Conceptual cross-sectionSiO₂·nH₂O
By the numbers · Measured metrics
Purity
0.0%
23-stage purification · UNIZ LAB R&D
Export · Countries
0+
A track record built with partners around the world
Research
0yr
Time spent refining and applying spicules
Dermal (pectolinarin) · Absorption
0.0%
Based on the model ingredient pectolinarin, porcine skin, in vitro · Kim TG 2022 · PMID 35034416
Technology · How it works
How spicules meet the skin, and how the skin responds
When fine channels open in the stratum corneum, active ingredients travel more easily toward the skin's depths, and older surface cells give way at their own pace. The diagrams and figures below are conceptual, grounded in verified academic literature and UNIZ LAB's own measurements.
Skin cross-section and microchannels
Schematic cross-section · Conceptual diagram
Source — Stratum corneum turnover cycle of 14 days (Halprin 1972). The principles of microchannel formation and transdermal delivery draw on transdermal delivery research in marine sponge (Haliclona sp.) and on microneedle-like principles. The figure above is conceptual.
Dermal absorption
Spicule-assisted · active ingredient pectolinarin
Model ingredient (pectolinarin) dermal absorption 73.4%
Model ingredient pectolinarin · porcine skin, in vitro · Kim TG 2022 (freshwater species-matched)
Physical penetration that opens microchannels
The natural mineral microneedle passes gently through the stratum corneum, creating fine pathways.
Delivery that reaches into the skin's depths
Along the opened pathways, active ingredients travel naturally into the skin's depths.
Physical stimulation from a natural mineral microneedle
Its amorphous SiO₂·nH₂O mineral structure physically opens fine pathways in the skin, delivering the same class of micro physical stimulation as MTS and Fraxel to support the skin's regeneration response (Drozdov 2021).
Kim TG 2022 · J Cosmet Dermatol · PMID 35034416 · DOI 10.1111/jocd.14771. The 73.4% dermal absorption is a value for the model ingredient (pectolinarin) measured in vitro on porcine skin (Franz diffusion cell), and is a freshwater species-matched measurement of UNIZ LAB spicules.
Specifications · Specs by size
Four sizes, precisely refined specifications
Choose a size and the particle-count visualization changes with it. Tap a column header to sort.
Sort ↑↓ · raise to highlight
| Size | Particles / g | Outer ø | Lumen (inner) | Aspect ratio |
|---|---|---|---|---|
| 100µm | 44.6M /g | 10µm | 1.0µm | 10 : 1 |
| 200µm | 16.4M /g | 13µm | 1.3µm | 15 : 1 |
| 270µm | 10.6M /g | 15µm | 1.5µm | 18 : 1 |
| 320µm | 10.3M /g | 13µm | 1.3µm | 25 : 1 |
Particles per gram · by size
Length · by size
UNIZ LAB Values from particle-size analysis and optical microscopy at ×100. The lumen (inner diameter) is 1/10 of the outer diameter — following the biomechanical ratio nature itself shaped.
Products · Product lineup
Spicule ingredients, chosen to fit your brand
From White Spicule to coating and impregnation, HA Spheres, and custom sizes — a complete lineup we bring to completion together with our OEM/ODM partners.
White Spicule
White Spicule
Our essential spicule, refined through 23 stages to 99.8% purity. It pairs well with the widest range of formulations.
Spec sheetCoating & Impregnation
Coating & Impregnation
By loading active ingredients onto the spicule surface and into its lumen, we design delivery efficiency exactly the way you want.
Spec sheet SignatureHA Sphere
HA Sphere
Hyaluronic acid spheres and spicules in one — microchannels and hydration brought together in a single ingredient.
Spec sheetMulti-Size
Multi-size
By blending 100 · 200 · 270 · 320µm together, we design depth and intensity layer by layer.
Spec sheetCustomized
Customized
From size to coating ingredients, a bespoke ingredient developed piece by piece to match the skin type your brand is targeting.
Learn moreEvidence · Scientific basis
Spicules, verified by science
UNIZ LAB cites only literature verifiable by PMID and DOI. Every figure below was confirmed directly from the original papers.
Peer-reviewed only · we cite only verified academic literature · species and sources specified
01
Spicule-mediated transdermal delivery of pectolinarin
Natural spicule transdermal delivery study — model ingredient (pectolinarin), porcine skin, in vitro, dermal absorption 73.4% · freshwater species-matched measurement
02
Skin retention profile of sponge spicules
Spicule skin retention 72h+ · acting as a reservoir that keeps active ingredients present longer (animal model)
03
Amorphous silica architecture of sponge spicules (²⁹Si NMR)
Sponge spicules = amorphous SiO₂·nH₂O mineral structure · ²⁹Si NMR Q⁴/Q³/Q²
Quality systems · Representative standards
ISO 9001
Quality Mgmt
ISO 22716
Cosmetics GMP
Gamma 25 kGy
Gamma sterilization
Heavy-metal
KCL compliant
The certifications above are representative examples; actual certificate numbers can be found in the technical documents (COA, MSDS, TDS).
Get started · B2B
Get your samples and technical documents
with ease.
We'll include the COA, MSDS, TDS, and particle-size analysis reports. Tell us the formulation you have in mind, and we'll suggest the size and coating that suit it best.
uniz@uniz.co.kr · 82-70-4109-6722