RESOURCESEvidence Hub
EVIDENCE HUB所有声称，
所有来源
您可以在一个页面中查看有关SPICULE原料的所有科学声称及其来源。这是R&D验证的综合参考资料。
16
TOTAL CLAIMS
20
REFERENCES
5
CATEGORIES
渗透力
(2个声称)| 声称 | 数值 | 来源 |
|---|---|---|
| Enhanced active ingredient penetration (microchannel transdermal delivery) | 향상 | 论文Kim, T. G., Lee, Y., Kim, M. S., & Lim, J.. (2022). "A novel dermal delivery system using natural spicules for cosmetics and therapeutics". Journal of Cosmetic Dermatology, 21(10), 4754–4764[原文] |
| 73.4% dermal absorption of the model ingredient (pectolinarin) — porcine skin, Franz diffusion cell, in vitro, liposome-loaded | 73.4% | 论文Kim, T. G., Lee, Y., Kim, M. S., & Lim, J.. (2022). "A novel dermal delivery system using natural spicules for cosmetics and therapeutics". Journal of Cosmetic Dermatology, 21(10), 4754–4764[原文] |
皮肤再生
(1个声称)| 声称 | 数值 | 来源 |
|---|---|---|
| Skin's own wound-healing response to physical micro-stimulation (microneedle/PCI-analogous principle; evidence is from needle/laser procedures, not spicule directly) | 论文El-Domyati, M., Barakat, M., Awad, S., et al.. (2015). "Microneedling therapy for atrophic acne scars: an objective evaluation". Journal of Clinical and Aesthetic Dermatology, 8(7)[原文] 论文Aust, M. C., Reimers, K., Repenning, C., et al.. (2011). "Percutaneous collagen induction: scarless skin rejuvenation — fact or fiction?". Journal of Plastic, Reconstructive & Aesthetic Surgery, 64(1)[原文] 论文Schmitt, L., Marquardt, Y., Amann, P., et al.. (2018). "Comprehensive molecular characterization of microneedling therapy in a human three-dimensional skin model". PLoS One, 13(9)[原文] 论文Fernandes, D.. (2005). "Minimally invasive percutaneous collagen induction". Oral and Maxillofacial Surgery Clinics of North America, 17(1)[原文] 论文Manstein, D., Herron, G. S., Sink, R. K., et al.. (2004). "Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury". Lasers in Surgery and Medicine, 34(5)[原文] |
物性·结构
(8个声称)| 声称 | 数值 | 来源 |
|---|---|---|
| 16,000 microchannels per cm² | 16,000/cm² | 自有UNIZ LAB R&D. (2022). "Microchannel density measurement of spicule-treated skin" |
| Stratum corneum implant effect with sustained delivery | 지속 | 论文Zhang Y et al.. (2017). "Spicule retention in skin (animal model): >72h". Mol. Pharm. |
| 100µm spicule: 44.6M particles per gram | 44.6M/g | 自有UNIZ LAB QC Lab. (2024). "Particle count verification by SEM analysis" |
| 200µm spicule: 16.4M particles per gram | 16.4M/g | 自有UNIZ LAB QC Lab. (2024). "Particle count verification by SEM analysis" |
| 270µm spicule: 10.6M particles per gram | 10.6M/g | 自有UNIZ LAB QC Lab. (2024). "Particle count verification by SEM analysis" |
| 320µm spicule: 10.3M particles per gram | 10.3M/g | 自有UNIZ LAB QC Lab. (2024). "Particle count verification by SEM analysis" |
| Elemental composition: O 51.8% / Si 36.3% / C 11.9% | 自有UNIZ LAB QC Lab. (2023). "EDS elemental analysis of spicule raw materials" | |
| 850 microchannels per mm² (avg depth 48.6µm · marine sponge study) | 850/mm² | 论文Zhang, C., Zhang, K., Zhang, J., et al.. (2019). "Skin delivery of hyaluronic acid by the combined use of sponge spicules and flexible liposomes". Biomaterials Science, 7(7)[原文] |
制造
(1个声称)| 声称 | 数值 | 来源 |
|---|---|---|
| 99.8% purity (23-step purification) | 99.8% | 自有UNIZ LAB QC Lab. (2024). "Purity verification report — 23-step purification process" |
安全性
(4个声称)| 声称 | 数值 | 来源 |
|---|---|---|
| Gamma sterilization (25 kGy) | 自有UNIZ LAB QC Lab. (2024). "Gamma sterilization compliance report" | |
| Heavy metal compliance (Pb, As, Hg, Cd) | 临床KCL (Korea Conformity Laboratories). (2024). "Heavy metal testing report" | |
| Cytotoxicity test: Cell viability > 90% | >90% | 自有UNIZ LAB R&D. (2023). "In vitro cytotoxicity assay — HaCaT cells" |
| Complete channel closure and barrier recovery within 120 hours (5 days) (marine sponge study) | 120h | 论文Zhang, C., Zhang, K., Zhang, J., et al.. (2019). "Skin delivery of hyaluronic acid by the combined use of sponge spicules and flexible liposomes". Biomaterials Science, 7(7)[原文] |