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Dual-Phase Action

How SPICULE
Transforms Skin

From microchannel formation to the skin's own wound-healing response — we explain SPICULE's two core mechanisms of action.

Active Ingredient Penetration
향상
Kim TG 2022, PMID 35034416
Barrier Recovery
120h
Sponge spicule study · channel closure (Zhang 2019, marine species)
Microchannel Density
조밀
Physical microchannels in stratum corneum
Mechanism Overview

Spicule's Dual-Phase Action Mechanism

BSPN SPICULE is an insoluble physical stimulation agent that performs a Dual-Phase action: physical microchannel formation → induction of the skin's own wound-healing response → natural elimination. It shares the same physical principle as microneedling and fractional treatments, and the skin itself — not SPICULE — is the source of regeneration.

↑ Click each card to view detailed mechanism for each phase

PHASE 01Drug Delivery System

Transdermal Drug Delivery Through Microchannels

When applied to skin, SPICULE creates microchannels in the stratum corneum through physical friction. Through these channels, transdermal absorption of active ingredients is dramatically enhanced. Compared to standard application, the penetration of active ingredients is significantly improved (Kim TG 2022, PMID 35034416).

1

SPICULE penetrates the stratum corneum, forming fine microchannels

2

Channels remain open and gradually close over up to 120 hours (5 days)

3

Active ingredients (ampoules, serums, etc.) are absorbed transdermally through the channels

4

Ingredients are delivered to the basal layer, accelerating the skin regeneration cycle

Microchannel Formation

다수

Spicules form densely distributed microchannels in the stratum corneum.

Skin Implant Effect

Sustained

Spicules continuously deliver active ingredients throughout the natural exfoliation cycle.

Enhanced Ingredient Penetration

향상

Through microchannels formed in the stratum corneum, the penetration of active ingredients is significantly improved compared to control (Kim TG 2022).
PENETRATION DATA

Penetration Enhancement by Ingredient

Total Active Ingredients

향상

vs. standard application

Model ingredient (pectolinarin) dermal absorption

73.4%

Porcine skin·Franz diffusion cell·in vitro·liposome·Kim 2022
Differentiation

BSPN Spicule's Differentiation vs. Other Ingredients

BSPN spicule is a distinctive ingredient category that combines physical active-ingredient delivery, physical micro-stimulation, and natural elimination — all in one.

Function
BSPN Spicule
Polymer MicroneedleGeneric Synthetic SilicaCollagen Booster Peptide
Physical Microchannel Formation✓ 16,000/cm²✓ (limited depth)✗✗
Macromolecule Dermal Delivery✓ Enhanced Penetration△ With patch only✗✗ Self only
Physical Micro-Stimulation (Induces Skin Wound-Healing · Needling-like)✓ Shares micro-stimulation principle△ Needle-type similar✗✗

BSPN Spicule = Multi-Functional Integrated Ingredient

Integrates physical active-ingredient delivery, physical micro-stimulation, and natural elimination into a single ingredient. While other ingredient categories provide only 1–2 functions, BSPN is a distinctive multi-functional ingredient that combines all three.

References

Academic & Technical References

All data, charts, and mechanism explanations on this page are based on peer-reviewed primary literature.

Peer-Reviewed Publications
  1. 1Kim TG, Lee Y, Kim MS, Lim J. (2022). A novel dermal delivery system using natural spicules for cosmetics and therapeutics. J Cosmet Dermatol, 21(10), 4754–4764. DOI: 10.1111/jocd.14771.
  2. 2El-Domyati M, Barakat M, Awad S, et al. (2015). Microneedling therapy for atrophic acne scars: an objective evaluation (마이크로니들 연구 · 인체 생검 콜라겐). J Clin Aesthet Dermatol, 8(7). PMID: 26203319.
  3. 3Aust MC, Reimers K, Repenning C, et al. (2011). Percutaneous collagen induction: scarless skin rejuvenation — fact or fiction? (경피 콜라겐 유도 · 성장인자). J Plast Reconstr Aesthet Surg, 64(1). PMID: 20413357.
  4. 4Schmitt L, Marquardt Y, Amann P, et al. (2018). Comprehensive molecular characterization of microneedling therapy in a human three-dimensional skin model (마이크로니들 연구 · 창상치유 유전자). PLoS One, 13(9). PMID: 30235356.
  5. 5Fernandes D. (2005). Minimally invasive percutaneous collagen induction (PCI · 물리적 미세자극 원리). Oral Maxillofac Surg Clin North Am, 17(1). PMID: 18088764.
  6. 6Manstein D, Herron GS, Sink RK, et al. (2004). Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury (프락셔널 레이저 · 물리 자극 원리). Lasers Surg Med, 34(5). PMID: 15216537.
  7. 7Drozdov AL, Zemnukhova LA, Panasenko AE, et al. (2021). Silicon Compounds in Sponges. Applied Sciences, 11(14), 6587. DOI: 10.3390/app11146587.
  8. 8Udompataikul M, Wongniraspai T. (2012). The study on effects and safety of Spongilla lacustris in 3% hydrogen peroxide solution on rat skin. J Med Assoc Thai, 95(Suppl 12), S15–S20. PMID: 23513460.
  9. 9Waghule T, et al. (2019). Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomedicine & Pharmacotherapy, 109, 1249–1258.
  10. 10Prausnitz MR, Langer R. (2008). Transdermal drug delivery. Nature Biotechnology, 26(11), 1261–1268.
  11. 11Zhang C, Zhang K, Zhang J, et al. (2019). Skin delivery of hyaluronic acid by the combined use of sponge spicules and flexible liposomes. Biomaterials Science, 7(7), 2821–2831. PMID: 30821312.
UNIZ LAB Internal Data
  1. 12UNIZ LAB R&D data — 99% high-purity, ~10.59 million particles per gram (270 µm), 23-step eco-enzyme purification process.
  2. 13Dong-A University EDS / XRD analysis report — Si 36.3% / O 51.8% / C 11.9%, X-ray amorphous pattern verified.
  3. 14Protechkorea Test Report (2022) — BET surface area 0.5968 m²/g (TriStar II 3020) / Density 2.0417 g/cm³ (AccuPyc II 1340, 5-cycle average ±0.0016).