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EVIDENCE HUBすべてのクレーム、
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SPICULE原料に関するすべての科学的主張とそのソースを1ページで確認できます。R&D検証用の総合リファレンスです。
17
TOTAL CLAIMS
21
REFERENCES
5
CATEGORIES
浸透力
(2個のクレーム)| クレーム | 数値 | ソース |
|---|---|---|
| Enhanced active ingredient penetration (microchannel transdermal delivery) | 향상 | 論文Kim, T. G., Lee, Y., Kim, M. S., & Lim, J.. (2022). "A novel dermal delivery system using natural spicules for cosmetics and therapeutics". Journal of Cosmetic Dermatology, 21(10), 4754–4764[原文] |
| 73.4% dermal absorption of the model ingredient (pectolinarin) — porcine skin, Franz diffusion cell, in vitro, liposome-loaded | 73.4% | 論文Kim, T. G., Lee, Y., Kim, M. S., & Lim, J.. (2022). "A novel dermal delivery system using natural spicules for cosmetics and therapeutics". Journal of Cosmetic Dermatology, 21(10), 4754–4764[原文] |
肌再生
(1個のクレーム)| クレーム | 数値 | ソース |
|---|---|---|
| Skin's own wound-healing response to physical micro-stimulation (microneedle/PCI-analogous principle; evidence is from needle/laser procedures, not spicule directly) | 論文El-Domyati, M., Barakat, M., Awad, S., et al.. (2015). "Microneedling therapy for atrophic acne scars: an objective evaluation". Journal of Clinical and Aesthetic Dermatology, 8(7)[原文] 論文Aust, M. C., Reimers, K., Repenning, C., et al.. (2011). "Percutaneous collagen induction: scarless skin rejuvenation — fact or fiction?". Journal of Plastic, Reconstructive & Aesthetic Surgery, 64(1)[原文] 論文Schmitt, L., Marquardt, Y., Amann, P., et al.. (2018). "Comprehensive molecular characterization of microneedling therapy in a human three-dimensional skin model". PLoS One, 13(9)[原文] 論文Fernandes, D.. (2005). "Minimally invasive percutaneous collagen induction". Oral and Maxillofacial Surgery Clinics of North America, 17(1)[原文] 論文Manstein, D., Herron, G. S., Sink, R. K., et al.. (2004). "Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury". Lasers in Surgery and Medicine, 34(5)[原文] |
物性・構造
(8個のクレーム)| クレーム | 数値 | ソース |
|---|---|---|
| 16,000 microchannels per cm² | 16,000/cm² | 自社UNIZ LAB R&D. (2022). "Microchannel density measurement of spicule-treated skin" |
| Stratum corneum implant effect with sustained delivery | 지속 | 論文Zhang Y et al.. (2017). "Spicule retention in skin (animal model): >72h". Mol. Pharm. |
| 100µm spicule: 44.6M particles per gram | 44.6M/g | 自社UNIZ LAB QC Lab. (2024). "Particle count verification by SEM analysis" |
| 200µm spicule: 16.4M particles per gram | 16.4M/g | 自社UNIZ LAB QC Lab. (2024). "Particle count verification by SEM analysis" |
| 270µm spicule: 10.6M particles per gram | 10.6M/g | 自社UNIZ LAB QC Lab. (2024). "Particle count verification by SEM analysis" |
| 320µm spicule: 10.3M particles per gram | 10.3M/g | 自社UNIZ LAB QC Lab. (2024). "Particle count verification by SEM analysis" |
| Elemental composition: O 51.8% / Si 36.3% / C 11.9% | 学会Material Characterization Center (물질특성분석센터). (2024). "SEM/EDS Analysis Report 24B-401-S (MCC-24B-401-1호) — SiO2 시료 · 의뢰 유니즈랩" | |
| 850 microchannels per mm² (avg depth 48.6µm · marine sponge study) | 850/mm² | 論文Zhang, C., Zhang, K., Zhang, J., et al.. (2019). "Skin delivery of hyaluronic acid by the combined use of sponge spicules and flexible liposomes". Biomaterials Science, 7(7)[原文] |
製造
(2個のクレーム)| クレーム | 数値 | ソース |
|---|---|---|
| 99% purity (23-step purification) | 99% | 自社UNIZ LAB QC Lab. (2024). "Purity verification report — 23-step purification process" |
| Silicon dioxide (SiO₂) content 99.7% | 99.7% | 論文Jensen M, Keding R, Yue Y. (2011). "Microscopic Features of Biologically Formed Amorphous Silica (On Biomimetics, IntechOpen), Table 1 — XRF of bleached freshwater sponge spicules: SiO₂ 99.7 wt% (SO₃ 0.041 · Fe₂O₃ 0.04 · TiO₂ 0.034 · K₂O 0.010 · P₂O₅ 0.005). CaO·Al₂O₃ excluded — the paper attributes them to sample handling and preparation." |
安全性
(4個のクレーム)| クレーム | 数値 | ソース |
|---|---|---|
| Gamma irradiation (25 kGy) | 自社UNIZ LAB QC Lab. (2024). "Gamma irradiation compliance report" | |
| Heavy metal compliance (Pb, As, Hg, Cd) | 臨床KCL (Korea Conformity Laboratories). (2024). "Heavy metal testing report" | |
| Cytotoxicity test: Cell viability > 90% | >90% | 自社UNIZ LAB R&D. (2023). "In vitro cytotoxicity assay — HaCaT cells" |
| Complete channel closure and barrier recovery within 120 hours (5 days) (marine sponge study) | 120h | 論文Zhang, C., Zhang, K., Zhang, J., et al.. (2019). "Skin delivery of hyaluronic acid by the combined use of sponge spicules and flexible liposomes". Biomaterials Science, 7(7)[原文] |